SUBJECTS : Biomedicine | Biology | Precision Medicine | Immunology | Genetics | Autoimmunit
JCI Insight: 2023, vol: , issue:
- 1)- Matthew T Patrick, Sutharzan Sreeskandarajan, Alanna Shefler, Rachael Wasikowski, Mrinal K Sarkar, Jiahan Chen, Tingting Qin, Allison C Billi, J Michelle Kahlenberg, Errol Prens, Alain Hovnanian, Stephan Weidinger, James T Elder, Chao-Chung Kuo, Johann E Gudjonsson, Lam C Tsoi. Large-scale functional inference for skin-expressing lncRNAs using expression and sequence information. JCI insight. 2023, 8 (24):
Cited : 1Read More - 2)- Guillaume Courbon, Dominik Kentrup, Jane Joy Thomas, Xueyan Wang, Hao-Hsuan Tsai, Jadeah Spindler, John Von Drasek, Laura Mazudie Ndjonko, Marta Martinez-Calle, Sana Lynch, Lauriane Hivert, Xiaofang Wang, Wenhan Chang, Jian Q Feng, Valentin David, Aline Martin. FGF23 directly inhibits osteoprogenitor differentiation in Dmp1-knockout mice. JCI insight. 2023, 8 (24): Cited : 2Read More
- 3)- Mollie F Qian, Romina J Bevacqua, Vy Mn Coykendall, Xiong Liu, Weichen Zhao, Charles A Chang, Xueying Gu, Xiao-Qing Dai, Patrick E MacDonald, Seung K Kim. HNF1α maintains pancreatic α and β cell functions in primary human islets. JCI insight. 2023, 8 (24): Cited : 3Read More
- 4)- Kevin P McGowan, Elizabeth Delgado, Theresa M Keeley, Elise S Hibdon, D Kim Turgeon, Elena M Stoffel, Linda C Samuelson. Region-specific Wnt signaling responses promote gastric polyp formation in patients with familial adenomatous polyposis. JCI insight. 2023, 8 (24): Cited : 0Read More
- 5)- Jiang Li, Byung Yoon Choi, Yasmin Eltawil, Noura Ismail Mohamad, Yesai Park, Ian R Matthews, Jin Hee Han, Bong Jik Kim, Elliott H Sherr, Dylan K Chan. TMTC4 is a hair cell-specific human deafness gene. JCI insight. 2023, 8 (24): Cited : 2Read More
- 6)- Omprakash Singh, Sean B Ogden, Salil Varshney, Kripa Shankar, Deepali Gupta, Subhojit Paul, Sherri Osborne-Lawrence, Corine P Richard, Nathan P Metzger, Connor Lawrence, Luis Leon Mercado, Jeffrey M Zigman. Ghrelin-responsive mediobasal hypothalamic neurons mediate exercise-associated food intake and exercise endurance. JCI insight. 2023, 8 (24): Cited : 1Read More
- 7)- Jiayu Chen, Qizhi Zheng, Jessica L Hicks, Levent Trabzonlu, Busra Ozbek, Tracy Jones, Ajay M Vaghasia, Tatianna C Larman, Rulin Wang, Mark C Markowski, Sam R Denmeade, Kenneth J Pienta, Ralph H Hruban, Emmanuel S Antonarakis, Anuj Gupta, Chi V Dang, Srinivasan Yegnasubramanian, Angelo M De Marzo. MYC-driven increases in mitochondrial DNA copy number occur early and persist throughout prostatic cancer progression. JCI insight. 2023, 8 (24): Cited : 1Read More
- 8)- Ziyu Chen, Soheila Ali Akbari Ghavimi, Mengfan Wu, John McNamara, Olga Barreiro, David Maridas, Radomir Kratchmarov, Ashley Siegel, Sarah Djeddi, Maria Gutierrez-Arcelus, Patrick J Brennan, Timothy P Padera, Ulrich von Andrian, Babak Mehrara, Arin K Greene, C Ronald Kahn, Dennis P Orgill, Indranil Sinha, Vicki Rosen, Shailesh Agarwal. PPARγ agonist treatment reduces fibroadipose tissue in secondary lymphedema by exhausting fibroadipogenic PDGFRα+ mesenchymal cells. JCI insight. 2023, 8 (24): Cited : 2Read More
- 9)- Amanda L Huff, Gabriella Longway, Jacob T Mitchell, Lalitya Andaloori, Emily Davis-Marcisak, Fangluo Chen, Melissa R Lyman, Rulin Wang, Jocelyn Mathew, Benjamin Barrett, Sabahat Rahman, James Leatherman, Mark Yarchoan, Nilofer S Azad, Srinivasan Yegnasubramanian, Luciane T Kagohara, Elana J Fertig, Elizabeth M Jaffee, Todd D Armstrong, Neeha Zaidi. CD4 T cell-activating neoantigens enhance personalized cancer vaccine efficacy. JCI insight. 2023, 8 (23): Cited : 4Read More
- 10)- Erik Melin, Are Hugo Pripp, Per Kristian Eide, Geir Ringstad. In vivo distribution of cerebrospinal fluid tracer in human upper spinal cord and brain stem. JCI insight. 2023, 8 (23): Cited : 2Read More
- 11)- Sailaja Battula, Gregory Papastoitsis, Howard L Kaufman, K Dane Wittrup, Michael M Schmidt. Intratumoral aluminum hydroxide-anchored IL-12 drives potent antitumor activity by remodeling the tumor microenvironment. JCI insight. 2023, 8 (23): Cited : 0Read More
- 12)- Hanjie Yu, Wen Xue, Hanqing Yu, Yaxiang Song, Xinying Liu, Ling Qin, Shu Wang, Hui Bao, Hongchen Gu, Guangqi Chen, Dake Zhao, Yang Tu, Jiafen Cheng, Liya Wang, Zisheng Ai, Dayong Hu, Ling Wang, Ai Peng. Single-cell transcriptomics reveals variations in monocytes and Tregs between gout flare and remission. JCI insight. 2023, 8 (23): Cited : 0Read More
- 13)- Rashmi Chandra, Arpine Sokratian, Katherine R Chavez, Stephanie King, Sandip M Swain, Joshua C Snyder, Andrew B West, Rodger A Liddle. Gut mucosal cells transfer α-synuclein to the vagus nerve. JCI insight. 2023, 8 (23): Cited : 13Read More
- 14)- Leila Probst, Sophie Monnerat, Deborah R Vogt, Sophia Lengsfeld, Thilo Burkard, Andrea Meienberg, Cemile Bathelt, Mirjam Christ-Crain, Bettina Winzeler. Effects of dulaglutide on alcohol consumption during smoking cessation. JCI insight. 2023, 8 (22): Cited : 5Read More
- 15)- Lie Chen, Cui-Cui Liu, Si-Yuan Zhu, Jing-Yu Ge, Yu-Fei Chen, Ding Ma, Zhi-Ming Shao, Ke-Da Yu. Multiomics of HER2-low triple-negative breast cancer identifies a receptor tyrosine kinase-relevant subgroup with therapeutic prospects. JCI insight. 2023, 8 (22): Cited : 4Read More
- 16)- Kun Jia, Jing Tian, Tienju Wang, Lan Guo, Zhenyu Xuan, Russell H Swerdlow, Heng Du. Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of Alzheimer disease. JCI insight. 2023, 8 (22): Cited : 1Read More
- 17)- Allison M Dubner, Sizhao Lu, Austin J Jolly, Keith A Strand, Marie F Mutryn, Tyler Hinthorn, Tysen Noble, Raphael A Nemenoff, Karen S Moulton, Mark W Majesky, Mary Cm Weiser-Evans. Smooth muscle-derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner. JCI insight. 2023, 8 (22): Cited : 1Read More
- 18)- Yun Liu, Jun Zhang, Fang Cao, Xiaobao Dong, Jie Li, Yanna Cao, Zhanglin Li, Yan Guo, Jie Yan, Yuanyuan Liu, Qiang Zhao. N6-methyladenosine-mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling. JCI insight. 2023, 8 (22): Cited : 0Read More
- 19)- Costanza Lo Cascio, Tigran Margaryan, Ernesto Luna-Melendez, James B McNamara, Connor I White, William Knight, Saisrinidhi Ganta, Zorana Opachich, Claudia Cantoni, Wonsuk Yoo, Nader Sanai, Artak Tovmasyan, Shwetal Mehta. Quisinostat is a brain-penetrant radiosensitizer in glioblastoma. JCI insight. 2023, 8 (22): Cited : 0Read More
- 20)- Kenji Takami, Kazuki Okamoto, Yuki Etani, Makoto Hirao, Akira Miyama, Gensuke Okamura, Atsushi Goshima, Taihei Miura, Takuya Kurihara, Yuji Fukuda, Takashi Kanamoto, Ken Nakata, Seiji Okada, Kosuke Ebina. Anti-NF-κB peptide derived from nuclear acidic protein attenuates ovariectomy-induced osteoporosis in mice. JCI insight. 2023, 8 (22): Cited : 1Read More
- 21)- Carolina Caro-Vegas, Alice Peng, Angelica Juarez, Allison Silverstein, William Kamiyango, Jimmy Villiera, Casey L McAtee, Rizine Mzikamanda, Tamiwe Tomoka, Erin C Peckham-Gregory, Razia Moorad, Carrie L Kovarik, Liane R Campbell, Parth S Mehta, Peter N Kazembe, Carl E Allen, Michael E Scheurer, Nmazuo W Ozuah, Dirk P Dittmer, Nader Kim El-Mallawany. Pediatric HIV+ Kaposi sarcoma exhibits clinical, virological, and molecular features different from the adult disease. JCI insight. 2023, 8 (22): Cited : 3Read More
- 22)- Anh Tp Ngo, Abigail Skidmore, Jenna Oberg, Irene Yarovoi, Amrita Sarkar, Nate Levine, Veronica Bochenek, Guohua Zhao, Lubica Rauova, M Anna Kowalska, Kaitlyn Eckart, Nilam S Mangalmurti, Ann Rux, Douglas B Cines, Mortimer Poncz, Kandace Gollomp. Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury. JCI insight. 2023, 8 (22): Cited : 2Read More
- 23)- Sadia Samer, Yanique Thomas, Mariluz Araínga, Crystal Carter, Lisa M Shirreff, Muhammad S Arif, Juan M Avita, Ines Frank, Michael D McRaven, Christopher T Thuruthiyil, Veli B Heybeli, Meegan R Anderson, Benjamin Owen, Arsen Gaisin, Deepanwita Bose, Lacy M Simons, Judd F Hultquist, James Arthos, Claudia Cicala, Irini Sereti, Philip J Santangelo, Ramon Lorenzo-Redondo, Thomas J Hope, Francois J Villinger, Elena Martinelli. Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. JCI insight. 2023, 8 (22): Cited : 0Read More
- 24)- Yiran Li, Mingyuan Han, Shilpi Singh, Haley A Breckenridge, Jordan E Kreger, Claudia C Stroupe, Daniel A Sawicky, Shiuhyang Kuo, Adam M Goldsmith, Fang Ke, Anukul T Shenoy, J Kelley Bentley, Ichiro Matsumoto, Marc B Hershenson. Tuft cells are required for a rhinovirus-induced asthma phenotype in immature mice. JCI insight. 2023, : Cited : 1Read More
- 25)- Carine Ciron, Pierre Morice, Juliette Rousse, Patrice Roy, Pierre-Joseph Royer, Olivier Gauthier, Sophie Brouard, Odile Duvaux, Firas Bassissi, Bernard Vanhove. New polyclonal antibodies, inhibit selectively tumor growth and invasion and synergize with immune checkpoint inhibitors. JCI insight. 2023, : Cited : 0Read More
- 26)- Li Wang, Panagiotis Tsakiroglou, Rex R Gonzales, Suhan Cho, Amy Li, Cristobal Dos Remedios, Nathan T Wright, Aikaterini Kontrogianni-Konstantopoulos. Essential role of obscurin kinase-1 in cardiomyocyte coupling via N-cadherin phosphorylation. JCI insight. 2023, : Cited : 1Read More
- 27)- Brendan K Huang, Brett M Elicker, Travis S Henry, Kimberly G Kallianos, Lewis D Hahn, Monica Tang, Franklin Heng, Charles E McCulloch, Nirav R Bhakta, Sharmila Majumdar, Jiwoong Choi, Loren C Denlinger, Sean B Fain, Annette T Hastie, Eric A Hoffman, Elliot Israel, Nizar N Jarjour, Bruce D Levy, David T Mauger, Kaharu Sumino, Sally E Wenzel, Mario Castro, Prescott G Woodruff, John V Fahy. Persistent mucus plugs in proximal airways are consequential for airflow limitation in asthma. JCI insight. 2023, : Cited : 1Read More
- 28)- Tarak Srivastava, Robert E Garola, Jianping Zhou, Varun Chandra Boinpelly, Mohammad H Rezaiekhaligh, Trupti Joshi, Yuexu Jiang, Diba Ebadi, Siddarth Sharma, Christine Sethna, Vincent S Staggs, Ram Sharma, Debbie S Gipson, Wei Hao, Yujie Wang, Laura H Mariani, Jeffrey B Hodgin, Robert Rottapel, Teruhito Yoshitaka, Yasuyoshi Ueki, Mukut Sharma. Scaffold protein SH3BP2 signalosome is pivotal for immune activation in nephrotic syndrome. JCI insight. 2023, : Cited : 1Read More
- 29)- Margaret M Lowe, Jarish N Cohen, Madison I Moss, Sean Clancy, James P Adler, Ashley E Yates, Haley B Naik, Rashi Yadav, Mariela Pauli, Ian Taylor, Austin McKay, Hobart Harris, Esther Kim, Scott L Hansen, Michael D Rosenblum, Joshua M Moreau. Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa. JCI insight. 2023, : Cited : 3Read More
- 30)- Evan L Barrios, Monty B Mazer, Patrick W McGonagill, Christian B Bergmann, Michael D Goodman, Robert W Gould, Mahil Rao, Valerie E Polcz, Ruth Davis, Drew Del Toro, Marvin Dirain, Alexandra Dram, Lucas Hale, Mohammad Heidarian, Caleb Y Kim, Tamara A Kucaba, Jennifer P Lanz, Ashley McCray, Alexandra Meszaros, Sydney M Miles, Candace Nelson, Ivanna Rocha, Elvia E Silva, Ricardo Ungaro, Andrew Walton, Julie Xu, Leilani Zeumer-Spataro, Anne M Drewry, Muxuan Liang, Letita E Bible, Tyler J Loftus, Isa. Adverse outcomes and an immune suppressed endotype in sepsis patients with reduced interferon-γ ELISpot. JCI insight. 2023, : Cited : 4Read More
- 31)- Anna S Pollack, Christian A Kunder, Noah Brazer, Zhewei Shen, Sushama Varma, Robert B West, Gerald R Cunha, Laurence S Baskin, James D Brooks, Jonathan R Pollack. Spatial transcriptomics identifies candidate stromal drivers of benign prostatic hyperplasia. JCI insight. 2023, : Cited : 3Read More
- 32)- Anna M Clark, Dongmei Yu, Grace Neiswanger, Daniel Zhu, Junhuang Zou, J Alan Maschek, Thomas Burgoyne, Jun Yang. Disruption of CFAP418 interaction with lipids causes widespread abnormal membrane-associated cellular processes in retinal degenerations. JCI insight. 2023, : Cited : 0Read More
- 33)- Pu-Hong Zhang, Wen-Wu Zhang, Shun-Shun Wang, Cheng-Hua Wu, Yang-Dong Ding, Xin-Yi Wu, Fang Gao Smith, Yu Hao, Jin Sheng-Wei. Efficient pulmonary lymphatic drainage is necessary for inflammation resolution in ARDS. JCI insight. 2023, : Cited : 3Read More
- 34)- Sanni Alve, Silvia Gramolelli, Joonas Jukonen, Susanna Juteau, Anne Pink, Atte A Manninen, Satu Hänninen, Elisa Monto, Madeleine H Lackman, Olli Carpén, Pipsa Saharinen, Sinem Karaman, Kari Vaahtomeri, Päivi M Ojala. DLL4-Notch3-WNT5B axis mediates bi-directional pro-metastatic crosstalk between melanoma and lymphatic endothelial cells. JCI insight. 2023, : Cited : 1Read More
- 35)- Arthur Liu, Seth T Gammon, Federica Pisaneschi, Akash Boda, Casey R Ager, David Piwnica-Worms, David S Hong, Michael A Curran. Hypoxia-activated prodrug and anti-angiogenic therapy cooperatively treat pancreatic cancer but elicit immunosuppressive G-MDSC infiltration. JCI insight. 2023, : Cited : 2Read More
- 36)- Kalina J Rossler, Willem J De Lange, Morgan W Mann, Timothy J Aballo, Jake A Melby, Jianhua Zhang, Gina Kim, Elizabeth F Bayne, Yanlong Zhu, Emily T Farrell, Timothy J Kamp, J Carter Ralphe, Ying Ge. Lactate and Immunomagnetic-purified hiPSC-derived cardiomyocytes generate comparable engineered cardiac tissue constructs. JCI insight. 2023, : Cited : 2Read More
- 37)- Michael K Kanan, Patrick W Sheehan, Jessica N Haines, Pedro G Gomez, Adya Dhuler, Collin J Nadarajah, Zachary M Wargel, Brittany M Freeberg, Hemanth R Nelvagal, Mariko Izumo, Joseph S Takahashi, Jonathan D Cooper, Albert A Davis, Erik S Musiek. Neuronal deletion of the circadian clock gene Bmal1 induces cell-autonomous dopaminergic neurodegeneration. JCI insight. 2023, : Cited : 6Read More
- 38)- Emily R Sechrest, Xiaojie Ma, Marion E Cahill, Robert J Barbera, Yixiao Wang, Wen-Tao Deng. Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation. JCI insight. 2023, : Cited : 1Read More
- 39)- Yan Zhu, Dengyong Zhang, Pooja Shukla, Young-Ho Jung, Prit Benny Malgulwar, Sharmeen Chagani, Medina Colic, Sarah Benjamin, John A Copland Iii, Lin Tan, Philip L Lorenzi, Milind Javle, Jason T Huse, Jason Roszik, Traver Hart, Lawrence N Kwong. CRISPR screening identifies BET and mTOR inhibitor synergy in cholangiocarcinoma through serine glycine one carbon. JCI insight. 2023, : Cited : 0Read More
- 40)- Tomasz W Kaminski, Tomasz Brzoska, Xiuying Li, Ravi Vats, Omika Katoch, Rikesh K Dubey, Kamal Bagale, Simon C Watkins, Bryan J McVerry, Tirthadipa Pradhan-Sundd, Lianghui Zhang, Keven M Robinson, Toru Nyunoya, Prithu Sundd. Lung microvascular occlusion by platelet-rich neutrophil-platelet aggregates promotes cigarette smoke induced severe flu. JCI insight. 2023, : Cited : 3Read More
- 41)- Shion Orikasa, Yuki Matsushita, Hiroaki Manabe, Michael Fogge, Zachary J Lee, Koji Mizuhashi, Naoko Sakagami, Wanida Ono, Noriaki Ono. Hedgehog activation promotes osteogenic fates of growth plate resting zone chondrocytes through transient clonal competency. JCI insight. 2023, : Cited : 4Read More
- 42)- Jan C Lumibao, Shira R Okhovat, Kristina L Peck, Xiaoxue Lin, Kathryn Lande, Shira Yomtoubian, Isabella Ng, Herve Tiriac, Andrew M Lowy, Jingjing Zou, Dannielle D Engle. The impact of extracellular matrix on the precision medicine utility of pancreatic cancer patient-derived organoids. JCI insight. 2023, : Cited : 2Read More
- 43)- Davis A Englund, Alyssa M Jolliffe, Gabriel J Hanson, Zaira Aversa, Xu Zhang, Xinyi Jiang, Thomas A White, Lei Zhang, David G Monroe, Paul D Robbins, Laura J Niedernhofer, Theodore M Kamenecka, Sundeep Khosla, Nathan K LeBrasseur. Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia. JCI insight. 2023, : Cited : 3Read More
- 44)- Santiago Alvarez-Argote, Samantha J Paddock, Michael A Flinn, Caelan W Moreno, Makenna C Knas, Victor A Almeida, Sydney L Buday, Amirala Bakhshian Nik, Michaela Patterson, Yi-Guang Chen, Chien-Wei Lin, Caitlin C O'Meara. Interleukin 13 promotes functional recovery after myocardial infarction via direct signaling to macrophages. JCI insight. 2023, : Cited : 5Read More
- 45)- Qi Cui, Tingting Jiang, Xinya Xie, Haodong Wang, Lei Qian, Yanyan Cheng, Qiang Li, Tingxu Lu, Qinyu Yao, Jia Liu, Baochang Lai, Chang Chen, Lei Xiao, Nanping Wang. S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury. JCI insight. 2023, : Cited : 0Read More
- 46)- Spencer G Miller, Catalina Matias, Paul S Hafen, Andrew S Law, Carol A Witczak, Jeffrey J Brault. Uric acid formation is driven by crosstalk between skeletal muscle and other cell types. JCI insight. 2023, : Cited : 2Read More
- 47)- Christine W Gao, WanYing Lin, Ryan C Riddle, Priyanka Kushwaha, Leandros Boukas, Hans T Björnsson, Kasper D Hansen, Jill A Fahrner. A mouse model of Weaver syndrome displays overgrowth and excess osteogenesis reversible with KDM6A/6B inhibition. JCI insight. 2023, : Cited : 2Read More
- 48)- Zhimin Chen, Peng Zhang, Tongyu Liu, Xiaoxue Qiu, Siming Li, Jiandie D Lin. Neuregulin 4 mediates the metabolic benefits of mild cold exposure by promoting beige fat thermogenesis. JCI insight. 2023, : Cited : 1Read More
- 49)- Honglin Liu, Zhenyu Han, Liru Chen, Jing Zhang, Zhanqing Zhang, Yaoxin Chen, Feichang Liu, Ke Wang, Jieyu Liu, Na Sai, Xinying Zhou, Chaoying Zhou, Shengfeng Hu, Qian Wen, Li Ma. ZNFX1 promotes AMPK-mediated autophagy against Mycobacterium tuberculosis by stabilizing mRNA. JCI insight. 2023, : Cited : 2Read More
