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  • npj Vaccines: 2023, vol: 8, issue: 1
  • 1)- Marta G Silva, Reginaldo G Bastos, Jacob M Laughery, Heba F Alzan, Vignesh A Rathinasamy, Brian M Cooke, Carlos E Suarez. Vaccination of cattle with the Babesia bovis sexual-stage protein HAP2 abrogates parasite transmission by Rhipicephalus microplus ticks. NPJ vaccines. 2023, 8 (1): 140
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  • 2)- Alexandra Fowler, Koen K A Van Rompay, Maureen Sampson, Javier Leo, Jennifer K Watanabe, Jodie L Usachenko, Ramya Immareddy, Debbie M Lovato, John T Schiller, Alan T Remaley, Bryce Chackerian. A virus-like particle-based bivalent PCSK9 vaccine lowers LDL-cholesterol levels in non-human primates. NPJ vaccines. 2023, 8 (1): 142
    Cited : 8
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  • 3)- Badiaa Bouzya, Ronan Nicolas Rouxel, Lionel Sacconnay, Romuald Mascolo, Laurence Nols, Stéphanie Quique, Loïc François, Anne Atas, Lucile Warter, Nancy Dezutter, Clarisse Lorin. Immunogenicity of an AS01-adjuvanted respiratory syncytial virus prefusion F (RSVPreF3) vaccine in animal models. NPJ vaccines. 2023, 8 (1): 143
    Cited : 2
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  • 4)- Ke Qiu, Xing Duan, Minzi Mao, Yao Song, Yufang Rao, Danni Cheng, Lan Feng, Xiuli Shao, Chuanhuan Jiang, Hai Huang, Yan Wang, Huifang Li, Xuemei Chen, Sisi Wu, Dan Luo, Fei Chen, Xingchen Peng, Yongbo Zheng, Haiyang Wang, Jun Liu, Yu Zhao, Xiangrong Song, Jianjun Ren. mRNA-LNP vaccination-based immunotherapy augments CD8 T cell responses against HPV-positive oropharyngeal cancer. NPJ vaccines. 2023, 8 (1): 144
    Cited : 6
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  • 5)- Mariann Gyöngyösi, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Patrick Einzinger, Andreas Spannbauer, Victor Schweiger, Katharina Schefberger, Eslam Samaha, Jutta Bergler-Klein, Martin Riesenhuber, Christian Nitsche, Christian Hengstenberg, Patrick Mucher, Helmuth Haslacher, Monika Breuer, Robert Strassl, Elisabeth Puchhammer-Stöckl, Christian Loewe, Dietrich Beitzke, Ena Hasimbegovic, Thomas A Zelniker. Effect of monovalent COVID-19 vaccines on viral interference between SARS-CoV-2 and several DNA viruses in patients with long-COVID syndrome. NPJ vaccines. 2023, 8 (1): 145
    Cited : 3
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  • 6)- Dan Liu, Rui Chen, Yong-Jing Wang, Wei Li, Li-Li Liu, Li-Rong Lin, Tian-Ci Yang, Man-Li Tong. Insights into the protective immune response by immunization with full-length recombinant TprK protein: cellular and humoral responses. NPJ vaccines. 2023, 8 (1): 146
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  • 7)- Lorna Leal, Judit Pich, Laura Ferrer, Jocelyn Nava, Ruth Martí-Lluch, Ignasi Esteban, Edwards Pradenas, Dàlia Raïch-Regué, Antoni Prenafeta, Karla Escobar, Carmen Pastor, Marc Ribas-Aulinas, Benjamin Trinitè, Jordana Muñoz-Basagoiti, Gemma Domenech, Bonaventura Clotet, Júlia Corominas, Aida Corpes-Comes, Carme Garriga, Antonio Barreiro, Nuria Izquierdo-Useros, Joan Albert Arnaiz, Alex Soriano, José Ríos, Marga Nadal, Montserrat Plana, Julià Blanco, Teresa Prat, Elia Torroella, Rafel Ramos, . Safety and immunogenicity of a recombinant protein RBD fusion heterodimer vaccine against SARS-CoV-2. NPJ vaccines. 2023, 8 (1): 147
    Cited : 1
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  • 8)- Liridona Maliqi, Nikolas Friedrich, Matthias Glögl, Stefan Schmutz, Daniel Schmidt, Peter Rusert, Merle Schanz, Maryam Zaheri, Chloé Pasin, Cyrille Niklaus, Caio Foulkes, Thomas Reinberg, Birgit Dreier, Irene Abela, David Peterhoff, Alexandra Hauser, Roger D Kouyos, Huldrych F Günthard, Marit J van Gils, Rogier W Sanders, Ralf Wagner, Andreas Plückthun, Alexandra Trkola. Assessing immunogenicity barriers of the HIV-1 envelope trimer. NPJ vaccines. 2023, 8 (1): 148
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  • 9)- Sabrina E Vinzón, María V Lopez, Eduardo G A Cafferata, Ariadna S Soto, Paula M Berguer, Luciana Vazquez, Leonora Nusblat, Andrea V Pontoriero, Eduardo M Belotti, Natalia R Salvetti, Diego L Viale, Ariel E Vilardo, Martin M Avaro, Estefanía Benedetti, Mara L Russo, María E Dattero, Mauricio Carobene, Maximiliano Sánchez-Lamas, Jimena Afonso, Mauro Heitrich, Alejandro E Cristófalo, Lisandro H Otero, Elsa G Baumeister, Hugo H Ortega, Alexis Edelstein, Osvaldo L Podhajcer. Cross-protection and cross-neutralization capacity of ancestral and VOC-matched SARS-CoV-2 adenoviral vector-based vaccines. NPJ vaccines. 2023, 8 (1): 149
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  • 10)- Michael Cheung, Cheng Chang, Raveen Rathnasinghe, Evan Rossignol, Yunfei Zhang, Annette Ferrari, Harsh Patel, Yanjun Huang, Michelle Sanchez Guillen, Tina Scalzo, Changkeun Lee, Gillis R Otten, Ethan C Settembre, Nedzad Music, Giuseppe Palladino, Yingxia Wen. Self-amplifying mRNA seasonal influenza vaccines elicit mouse neutralizing antibody and cell-mediated immunity and protect ferrets. NPJ vaccines. 2023, 8 (1): 150
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  • 11)- Shilin Zhao, Kris Y W Lok, Zhen Y Sin, Ye Peng, Heidi S L Fan, Nitya Nagesh, Martha S L Choi, Jojo Y Y Kwok, Edmond P H Choi, Xi Zhang, Hogan Kok-Fung Wai, Leo C H Tsang, Samuel S M Cheng, Matthew K L Wong, Jie Zhu, Chris K P Mok, Siew C Ng, Francis K L Chan, Malik Peiris, Leo L M Poon, Hein M Tun. COVID-19 mRNA vaccine-mediated antibodies in human breast milk and their association with breast milk microbiota composition. NPJ vaccines. 2023, 8 (1): 151
    Cited : 1
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  • 12)- Filippo Carboni, Roberta Cozzi, Giacomo Romagnoli, Giovanna Tuscano, Cristiana Balocchi, Giada Buffi, Margherita Bodini, Cecilia Brettoni, Fabiola Giusti, Sara Marchi, Giulia Brogioni, Barbara Brogioni, Paolo Cinelli, Luigia Cappelli, Chiara Nocciolini, Silvia Senesi, Claudia Facciotti, Elisabetta Frigimelica, Monica Fabbrini, Daniela Stranges, Silvana Savino, Domenico Maione, Benjamin Wizel, Immaculada Margarit, Maria Rosaria Romano. Proof of concept for a single-dose Group B Streptococcus vaccine based on capsular polysaccharide conjugated to Qβ virus-like particles. NPJ vaccines. 2023, 8 (1): 152
    Cited : 3
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  • 13)- Mingyuan Li, Lin Jia, Yanbo Xie, Wenlin Ma, Zhihong Yan, Fufeng Liu, Jie Deng, Ali Zhu, Xue Siwei, Wen Su, Xiaofeng Liu, Shiqin Li, Haomeng Wang, Peng Yu, Tao Zhu. Lyophilization process optimization and molecular dynamics simulation of mRNA-LNPs for SARS-CoV-2 vaccine. NPJ vaccines. 2023, 8 (1): 153
    Cited : 2
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  • 14)- Sarah M Valencia, Eric Rochat, Melissa J Harnois, Maria Dennis, Helen S Webster, Bhavna Hora, Amit Kumar, Hsuan-Yuan Sherry Wang, Leike Li, Daniel Freed, Ningyan Zhang, Zhiqiang An, Dai Wang, Sallie R Permar. Vaccination with a replication-defective cytomegalovirus vaccine elicits a glycoprotein B-specific monoclonal antibody repertoire distinct from natural infection. NPJ vaccines. 2023, 8 (1): 154
    Cited : 0
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  • 15)- Ryan Mazboudi, Hannah Mulhall Maasz, Matthew D Resch, Ke Wen, Paul Gottlieb, Aleksandra Alimova, Reza Khayat, Natalie D Collins, Robert A Kuschner, Jose M Galarza. A recombinant virus-like particle vaccine against adenovirus-7 induces a potent humoral response. NPJ vaccines. 2023, 8 (1): 155
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  • 16)- Lizhou Zhang, Kunal R More, Amrita Ojha, Cody B Jackson, Brian D Quinlan, Hao Li, Wenhui He, Michael Farzan, Norbert Pardi, Hyeryun Choe. Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability. NPJ vaccines. 2023, 8 (1): 156
    Cited : 16
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  • 17)- Christina M Kackos, Jennifer DeBeauchamp, Christopher J H Davitt, Jan Lonzaric, Robert E Sealy, Julia L Hurwitz, Marcelo M Samsa, Richard J Webby. Seasonal quadrivalent mRNA vaccine prevents and mitigates influenza infection. NPJ vaccines. 2023, 8 (1): 157
    Cited : 1
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  • 18)- Rocky Lai, Abiola F Ogunsola, Tasfia Rakib, Samuel M Behar. Key advances in vaccine development for tuberculosis-success and challenges. NPJ vaccines. 2023, 8 (1): 158
    Cited : 9
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  • 19)- Henning Jacobsen, Ioannis Sitaras, Maeva Katzmarzyk, Viviana Cobos Jiménez, Robert Naughton, Melissa M Higdon, Maria Deloria Knoll. Systematic review and meta-analysis of the factors affecting waning of post-vaccination neutralizing antibody responses against SARS-CoV-2. NPJ vaccines. 2023, 8 (1): 159
    Cited : 5
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  • 20)- Awadalkareem Adam, Birte Kalveram, John Yun-Chung Chen, Jason Yeung, Leslie Rodriguez, Ankita Singh, Pei-Yong Shi, Xuping Xie, Tian Wang. A single-dose of intranasal vaccination with a live-attenuated SARS-CoV-2 vaccine candidate promotes protective mucosal and systemic immunity. NPJ vaccines. 2023, 8 (1): 160
    Cited : 1
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  • 21)- Nidhi Mittal, Sahil Kumar, Raju S Rajmani, Randhir Singh, Céline Lemoine, Virginie Jakob, Sowrabha Bj, Nayana Jagannath, Madhuraj Bhat, Debajyoti Chakraborty, Suman Pandey, Aurélie Jory, Suba Soundarya Sa, Harry Kleanthous, Patrice Dubois, Rajesh P Ringe, Raghavan Varadarajan. Enhanced protective efficacy of a thermostable RBD-S2 vaccine formulation against SARS-CoV-2 and its variants. NPJ vaccines. 2023, 8 (1): 161
    Cited : 1
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  • 22)- Chunyuan Xie, Ruhui Yao, Xiaojun Xia. The advances of adjuvants in mRNA vaccines. NPJ vaccines. 2023, 8 (1): 162
    Cited : 8
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  • 23)- Simon Doss-Gollin, Sanya Thomas, Byron Brook, Kimia Abedi, Célia Lebas, Floriane Auderset, Yamile Lugo-Rodriguez, Guzman Sanchez-Schmitz, David J Dowling, Ofer Levy, Simon D van Haren. Human in vitro modeling of adjuvant formulations demonstrates enhancement of immune responses to SARS-CoV-2 antigen. NPJ vaccines. 2023, 8 (1): 163
    Cited : 2
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  • 24)- Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen. A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques. NPJ vaccines. 2023, 8 (1): 164
    Cited : 0
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  • 25)- Yazmin B Martinez-Martinez, Matthew B Huante, Sadhana Chauhan, Kubra F Naqvi, Preeti Bharaj, Janice J Endsley. Helper T cell bias following tuberculosis chemotherapy identifies opportunities for therapeutic vaccination to prevent relapse. NPJ vaccines. 2023, 8 (1): 165
    Cited : 0
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  • 26)- Daniel Cadarette, Maddalena Ferranna, Jeffrey W Cannon, Kaja Abbas, Fiona Giannini, Leo Zucker, David E Bloom. The full health, economic, and social benefits of prospective Strep A vaccination. NPJ vaccines. 2023, 8 (1): 166
    Cited : 7
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  • 27)- Jae-Yong Kim, Kyeongseok Jeon, Sang-In Park, Yoo-Jin Bang, Hyeong-Jun Park, Hye Won Kwak, Do-Hyung Kim, Soo-Yeon Lee, Eun-Jin Choi, Nam-Hyuk Cho, Jae-Hwan Nam. mRNA vaccine encoding Gn provides protection against severe fever with thrombocytopenia syndrome virus in mice. NPJ vaccines. 2023, 8 (1): 167
    Cited : 3
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  • 28)- Hirotaka Fukami, Jun Morinaga, Hironori Nakagami, Hiroki Hayashi, Yusuke Okadome, Eiji Matsunaga, Tsuyoshi Kadomatsu, Haruki Horiguchi, Michio Sato, Taichi Sugizaki, Keishi Miyata, Daisuke Torigoe, Masashi Mukoyama, Ryuichi Morishita, Yuichi Oike. Efficacy and safety in mice of repeated, lifelong administration of an ANGPTL3 vaccine. NPJ vaccines. 2023, 8 (1): 168
    Cited : 1
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  • 29)- Haiyang Wang, Yisha Wang, Changzheng Yuan, Xiao Xu, Wenbin Zhou, Yuhui Huang, Huan Lu, Yue Zheng, Gan Luo, Jia Shang, Meihua Sui. Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats. NPJ vaccines. 2023, 8 (1): 169
    Cited : 2
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  • 30)- Mingqing Lu, Yanfeng Yao, Xuekai Zhang, Hang Liu, Ge Gao, Yun Peng, Miaoyu Chen, Jiaxuan Zhao, XiaoYu Zhang, Chunhong Yin, Weiwei Guo, Peipei Yang, Xue Hu, Juhong Rao, Entao Li, Tong Chen, Sandra Chiu, Gary Wong, Zhiming Yuan, Jiaming Lan, Chao Shan. Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection. NPJ vaccines. 2023, 8 (1): 170
    Cited : 3
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  • 31)- Cigdem Alkan, Eduardo Jurado-Cobena, Tetsuro Ikegami. Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates. NPJ vaccines. 2023, 8 (1): 171
    Cited : 5
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  • 32)- Bailey E Maloney, Kassandra L Carpio, Ashley N Bilyeu, Danielle R D Saunders, So Lee Park, Adrienne E Pohl, Natalia Costa Ball, Janae L Raetz, Claire Y Huang, Stephen Higgs, Alan D T Barrett, Gleyder Roman-Sosa, Joanie L Kenney, Dana L Vanlandingham, Yan-Jang S Huang. Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine. NPJ vaccines. 2023, 8 (1): 172
    Cited : 0
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  • 33)- Swetha Parvathaneni, Jiyeon Yang, Leda Lotspeich-Cole, Jiro Sakai, Robert C Lee, Mustafa Akkoyunlu. IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells. NPJ vaccines. 2023, 8 (1): 173
    Cited : 2
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  • 34)- Marie Alexandre, Mélanie Prague, Chelsea McLean, Viki Bockstal, Macaya Douoguih, Rodolphe Thiébaut, . Prediction of long-term humoral response induced by the two-dose heterologous Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola. NPJ vaccines. 2023, 8 (1): 174
    Cited : 0
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  • 35)- Archana V Boopathy, Bhawna Sharma, Anurag Nekkalapudi, Raphaela Wimmer, Maria Gamez-Guerrero, Silpa Suthram, Hoa Truong, Johnny Lee, Jiani Li, Ross Martin, Wade Blair, Romas Geleziunas, Klaus Orlinger, Sarah Ahmadi-Erber, Henning Lauterbach, Tariro Makadzange, Brie Falkard, Sarah Schmidt. Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys. NPJ vaccines. 2023, 8 (1): 175
    Cited : 1
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  • 36)- Maarten Swart, Harmjan Kuipers, Fin Milder, Mandy Jongeneelen, Tina Ritschel, Jeroen Tolboom, Leacky Muchene, Joan van der Lubbe, Ana Izquierdo Gil, Daniel Veldman, Jeroen Huizingh, Johan Verspuij, Sonja Schmit-Tillemans, Sven Blokland, Martijn de Man, Ramon Roozendaal, Christopher B Fox, Hanneke Schuitemaker, Martinus Capelle, Johannes P M Langedijk, Roland Zahn, Boerries Brandenburg. Enhancing breadth and durability of humoral immune responses in non-human primates with an adjuvanted group 1 influenza hemagglutinin stem antigen. NPJ vaccines. 2023, 8 (1): 176
    Cited : 0
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  • 37)- Chon Phin Ong, Kaiming Tang, Pak-Hin Hinson Cheung, Hongzhuo Zhang, Tze-Tung Tang, Yaqian Xue, Junjue Wang, Kelvin Kai-Wang To, Shuofeng Yuan, Zi-Wei Ye, Dong-Yan Jin. Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants. NPJ vaccines. 2023, 8 (1): 177
    Cited : 0
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  • 38)- B Adam Williams, Charles H Jones, Verna Welch, Jane M True. Outlook of pandemic preparedness in a post-COVID-19 world. NPJ vaccines. 2023, 8 (1): 178
    Cited : 7
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  • 39)- Rajesh M Valanparambil, Lilin Lai, Margaret A Johns, Meredith Davis-Gardner, Susanne L Linderman, Tarrant Oliver McPherson, Andres Chang, Akil Akhtar, Estefany L Bocangel Gamarra, Hayley Matia, Ashley A McCook-Veal, Jeffrey Switchenko, Tahseen H Nasti, Felicia Green, Manpreet Saini, Andreas Wieland, Benjamin A Pinsky, Daniel Solis, Madhav V Dhodapkar, Jennifer Carlisle, Suresh Ramalingam, Rafi Ahmed, Mehul S Suthar. BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer. NPJ vaccines. 2023, 8 (1): 179
    Cited : 0
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  • 40)- Maria P Gorenflo, Pamela B Davis, David C Kaelber, Rong Xu. Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States. NPJ vaccines. 2023, 8 (1): 180
    Cited : 3
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  • 41)- Shamim Ahmed, Durgadevi Parthasarathy, Rachael Newhall, Tashina Picard, Morgainne Aback, Sneha Ratnapriya, William Arndt, Widaliz Vega-Rodriguez, Natalie M Kirk, Yuying Liang, Alon Herschhorn. Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens. NPJ vaccines. 2023, 8 (1): 181
    Cited : 3
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  • 42)- Diana Moita, Catarina Rôla, Helena Nunes-Cabaço, Gonçalo Nogueira, Teresa G Maia, Ahmad Syibli Othman, Blandine Franke-Fayard, Chris J Janse, António M Mendes, Miguel Prudêncio. The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria. NPJ vaccines. 2023, 8 (1): 182
    Cited : 2
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  • 43)- Danielle Nettere, Shakthi Unnithan, Nicole Rodgers, Junsuke Nohara, Paul Cray, Madison Berry, Caroline Jones, Lawrence Armand, Shuk Hang Li, Stella J Berendam, Genevieve G Fouda, Derek W Cain, Taylor N Spence, Joshua A Granek, Clemontina A Davenport, Robert J Edwards, Kevin Wiehe, Koen K A Van Rompay, M Anthony Moody, Sallie R Permar, Justin Pollara. Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques. NPJ vaccines. 2023, 8 (1): 183
    Cited : 0
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  • 44)- Desmond Curran, T Mark Doherty, Nicolas Lecrenier, Thomas Breuer. Healthy ageing: Herpes zoster infection and the role of zoster vaccination. NPJ vaccines. 2023, 8 (1): 184
    Cited : 3
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  • 45)- Ting Bian, Meng Hao, Xiaofan Zhao, Chuanyi Zhao, Gang Luo, Zhendong Zhang, Guangcheng Fu, Lu Yang, Yi Chen, Yudong Wang, Changming Yu, Yilong Yang, Jianmin Li, Wei Chen. Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques. NPJ vaccines. 2023, 8 (1): 185
    Cited : 0
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  • 46)- Maartje R Inklaar, Roos M de Jong, Ezra T Bekkering, Hikaru Nagaoka, Felix L Fennemann, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Stoter, C Richter King, Nicholas I Proellochs, Teun Bousema, Eizo Takashima, Takafumi Tsuboi, Matthijs M Jore. Pfs230 Domain 7 is targeted by a potent malaria transmission-blocking monoclonal antibody. NPJ vaccines. 2023, 8 (1): 186
    Cited : 1
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  • 47)- Nawapol Kunkeaw, Wang Nguitragool, Eizo Takashima, Niwat Kangwanrangsan, Hiromi Muramatsu, Mayumi Tachibana, Tomoko Ishino, Paulo J C Lin, Ying K Tam, Sathit Pichyangkul, Takafumi Tsuboi, Norbert Pardi, Jetsumon Sattabongkot. A Pvs25 mRNA vaccine induces complete and durable transmission-blocking immunity to Plasmodium vivax. NPJ vaccines. 2023, 8 (1): 187
    Cited : 1
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  • 48)- Lizette Elaine Rios, Nandadeva Lokugamage, Subhadip Choudhuri, Imran Hussain Chowdhury, Nisha Jain Garg. Subunit nanovaccine elicited T cell functional activation controls Trypanosoma cruzi mediated maternal and placental tissue damage and improves pregnancy outcomes in mice. NPJ vaccines. 2023, 8 (1): 188
    Cited : 0
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  • 49)- Julie Zimmermann, Simon D van Haren, Joann Arce, Ignatius Ryan Adriawan, Katharina Wørzner, Ricki T Krog, Safia Guleed, Tu Hu, Rasmus Mortensen, Jes Dietrich, Sara M Ø Solbak, Ofer Levy, Dennis Christensen, Gabriel K Pedersen. Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells. NPJ vaccines. 2023, 8 (1): 189
    Cited : 0
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  • 50)- Sandro Roier, Vidya Mangala Prasad, Monica M McNeal, Kelly K Lee, Benjamin Petsch, Susanne Rauch. mRNA-based VP8* nanoparticle vaccines against rotavirus are highly immunogenic in rodents. NPJ vaccines. 2023, 8 (1): 190
    Cited : 2
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